Figure 2.
Immunogold labeling of capsid display recombinant G2. Purified G2 and wild type Ad5 virus particles were reacted first with anti-NANP monoclonal antibody 2A10 and then with rabbit anti-mouse IgG secondary antibody conjugated to 2nM gold beads. Electron micrographs of negatively-stained samples show that recombinant (A) but not wild-type Ad5 (B) virions are reactive with the NANP antibody as indicated by decoration by the gold-labeled secondary antibody (arrows). The four virions shown are taken from different negatives. Brightness and contrast were adjusted individually for clarity and consistency of appearance.
