Figure 1.

Schematics of novel multimodal CARS microscopy to monitor inflammatory neurodegeneration. (a) Experimental schema of EAE induced in various strains. Tissue from spinal cord or forebrain was dissected and transferred to imaging slides of the multimodal CARS microscope. (b) Models of EAE used in the study, EAE in C57BL6 immunized with MOG 35–55 produces a chronic model of MS with an initial acute phase that leads to a chronic stable phase. (c) SJL strain develop a relapsing remitting disease when immunized with PLP 139–151, which resembles a similar course that is observed in many MS patients.