Figure 3.
Ih channels in VTA DA neurons were involved in defeat-induced avoidance behavior and action of fluoxetine. A, Ih currents were elicited by repetitive 800 ms pulses with 10 mV increments from a holding potential of −60 to −140 mV. Sample traces recorded from control-vehicle, susceptible-vehicle, and susceptible-fluoxetine mice. B, Chronic social defeat increased Ih currents in VTA DA neurons, which was almost completely reversed by chronic treatment with fluoxetine (***p < 0.0001 vs control-vehicle mice, ## p < 0.01 vs susceptible-fluoxetine mice, n = 35–66 cells, 10–12 mice/group). C, Infusion of Ih channel inhibitor ZD7288 or DK-AH 269 into VTA significantly reversed the stress-induced social avoidance (**p < 0.01, ***p < 0.001; n = 6–11 mice).