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. Author manuscript; available in PMC: 2012 Mar 7.
Published in final edited form as: J Immunol Methods. 2011 Jan 19;366(1-2):43–51. doi: 10.1016/j.jim.2011.01.002

Figure 2.

Figure 2

Function of modified TCRs after individual alanine substitutions in either CDR2 or CDR3 of α or β chain. Anti-CD3 stimulated PBL were transduced with each modified TCR, co-cultured with RCC and melanoma lines and tested for IFN-γ production as described in Figure 1B. WT represents the native unmodified TCR.

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