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. 2011 Mar;79(3):411–419. doi: 10.1124/mol.110.069492

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Copyright © 2011 The American Society for Pharmacology and Experimental Therapeutics

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Fig. 4. — Permanently charged D575 produces block when included in the pipette. Mean peak currents ± S.E.M., normalized to the first pulse of the train and with mean control values subtracted. D575 (200 μM) produced 47 ± 1% block when stepped to −30 mV (■), 63 ± 1% block when stepped to −10 mV (□), and 75 ± 2% block when stepped to +10 mV () (n = 8). Left inset, representative currents elicited by repetitive depolarizations from −110 to −10 mV with an interpulse interval of 100 ms in a cell recorded with 200 μM D575 included in the pipette. Right inset, τ values from exponential fits show voltage-dependence for D575 (■, n = 8).

Inline graphic — Permanently charged D575 produces block when included in the pipette. Mean peak currents ± S.E.M., normalized to the first pulse of the train and with mean control values subtracted. D575 (200 μM) produced 47 ± 1% block when stepped to −30 mV (■), 63 ± 1% block when stepped to −10 mV (□), and 75 ± 2% block when stepped to +10 mV () (n = 8). Left inset, representative currents elicited by repetitive depolarizations from −110 to −10 mV with an interpulse interval of 100 ms in a cell recorded with 200 μM D575 included in the pipette. Right inset, τ values from exponential fits show voltage-dependence for D575 (■, n = 8).

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