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Elevated [Ca2+]rest in heterozygous (Het) R163C myotubes and adult fibers. Microelectrode measurements of [Ca2+]rest in cultured myotubes and in adult vastus lateralis fibers in vivo were made as described under Materials and Methods. The data shown are mean ± S.E.M. [Ca2+]rest values, which differed significantly between WT and R163C for both cultured myotubes and adult fibers (***, p < 0.001).
