Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Equilibrium dissociation constants. A, the affinity of the resting αG147S AChR for ACh was estimated from the Po dose-response profile. B, Kd values for choline were estimated for αG153S by fitting interval durations across concentrations. The rate constants and Kd values for all αGly153 mutants were similar and are given in Supplemental Table S4.
