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. 2001 Mar 13;98(6):3104–3108. doi: 10.1073/pnas.051635998

Figure 4.

Figure 4

FAS active center constituted by DI and DII–DIII and the individual catalytic reactions involved in the synthesis butyryl-intermediate and its subsequent elongation to palmitate. As described above, 10 reactions are involved in the formation of butyryl–S-KS, which undergoes bracketed reactions six more times to generate palmitoyl-S-ACP, which is released by TE. The complexity and the repetitive nature of these reactions are the basis of our proposal that the ACP carrying the acyl-intermediates and the catalytic activity are in dynamic state and that the ID sequences that do not participate in these catalytic reactions play an important role in holding together the two subunits of FAS.