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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Placenta. 2011 Feb 4;32(Suppl 2):S182–S185. doi: 10.1016/j.placenta.2011.01.009

Fig. 1.

Fig. 1

Dysregulation of hCG may lead to preeclampsia. In normal pregnancy, functional hCG, optimum expression of IL-10, and the temporal appearance of uNK and Tregs contribute to immune tolerance and angiogenesis. Dysregulated hCG due to altered structure/glycosylation may influence expression of IL-10, IDO and appearance of Tregs and uNK cells resulting in pregnancy complications such as preeclampsia. hCG: human chorionic gonadotropin, IL-10: interleukin-10, IDO: indoleamine 2,3-dioxygenase, uNK : uterine natural killer cells, Treg: regulatory T cells, ET: endovascular trophoblasts.