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. Author manuscript; available in PMC: 2012 Mar 3.
Published in final edited form as: Vaccine. 2011 Jan 6;29(11):2131–2139. doi: 10.1016/j.vaccine.2010.12.087

Figure 4.

Figure 4

Systemic anti-OprF humoral response following mucosal immunization. C57BL/6 mice were immunized with AdC7OprF, AdOprF, Ad5Null or AdC7Null at a dose of 1010 pu/mouse. A. Serum anti-OprF IgG antibodies 0, 4, 8 and 12 wk after administration analyzed by ELISA using recombinant OprF as antigen. B. Serum anti-OprF IgG1, IgG2a, IgG2b and IgG3 antibodies 8 wk following administration. Data are shown as mean ± SEM, n=4/group, of one of three representative experiments. The dashed line represents the limit of detection. *, ** and *** denote significance of p<0.05, p<0.01 and p<0.001, respectively, between AdC7OprF and Ad5OprF.