Table 1.

Summary of Immunohistochemistry and Molecular Results for p53, IDH1/2 and Chromosome 7 in 21 WHO Grade II Diffuse Astrocytomas

	Immunohistochemistry			Molecular Tests
Case #	p53	Mutant- specific (R132H) IDH1	IDH1 SNaPshot	IDH2 SNaPshot	TP53 SNaPshot	FISH (+7)
xT 6302	--	--	WT	WT	WT	+
xT 6303	+	+	R132H	WT	R273C	+
xT 6375	+	--	WT	WT	WT	+
xT 5344	+	+	R132H	WT	WT	+
xT 6304	--	+	R132H	WT	WT	+
xT 6029	+	--	R 132C	WT	WT	+
xT 4852	--	--	WT	WT	WT	+
xT 4829	+	+	R132H	WT	R175H	+
xT 4917	--	--	WT	WT	WT	--
xT 3991	--	--	WT	R172K	WT	+
xT 4237	--	+	R132H	WT	WT	--
xT 3798	--	+	R132H	WT	WT	--
xT 6305	--	+	R132H	WT	WT	--
xT 3362	--	--	WT	WT	WT	+
xT 3247	--	--	R132G	WT	WT	+
xT 3539	+	--	R132C	WT	R273C	+
xT 6171	+	+	R132H	WT	WT	--
xT 6376	--	+	R132H	WT	WT	+
xT 6306	+	+	R132H	WT	R248Q	+
xT 4334	+	--	WT	WT	WT	+
xT 6377	+	--	R132C	WT	WT	+

+7: copy number gain of chromosome 7

-- = negative; + = positive; FISH = fluorescence in situ hybridization; WT: wild-type IDH1/2 = isocitrate dehydrogenase 1/2.