Table 2.
Sensitivity and Specificity Values and Positive and Negative Predictive Values of Single and Combined Tests for the Diagnosis of WHO Grade II Diffuse Astrocytomas
| p53 | Mutant-specific (R132H) IDH1 |
IDH1 SNaPshot |
FISH (+7) | Sensitivity (%) |
Specificity (%) |
PPV | NPV |
|---|---|---|---|---|---|---|---|
| X | 47.6 | 100 | 100 | 64.5 | |||
| X | 47.6 | 100 | 100 | 64.5 | |||
| X | 66.7 | 100 | 100 | 74 | |||
| X | 76.2 | 100 | 100 | 80 | |||
| X | X | 71.4 | 100 | 100 | 76.9 | ||
| X | X | 76.2 | 100 | 100 | 80 | ||
| X | X | 80.9 | 100 | 100 | 83.3 | ||
| X | X | 66.7 | 100 | 100 | 74 | ||
| X | X | 95 | 100 | 100 | 95 | ||
| X | X | 95 | 100 | 100 | 95 | ||
| X | X | X | 76.2 | 100 | 100 | 80 | |
| X | X | X | 95 | 100 | 100 | 95 | |
| X | X | X | 95 | 100 | 100 | 95 | |
| X | X | X | 95 | 100 | 100 | 95 | |
| X | X | X | X | 95 | 100 | 100 | 95 |
X = test applied; PPV = positive predictive value; NPV = negative predictive value; FISH = fluorescence in situ hybridization; IDH1 = isocitrate dehydrogenase.