. Author manuscript; available in PMC: 2012 Jan 1.

Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2010 Nov 10;20(1):57–69. doi: 10.1158/1055-9965.EPI-10-0843

Table 1.

Summary of SNPs


						Colon		Rectal
Gene	Alias	Location	SNP	Major/ Minor Allele	MAF1	Heterozygote OR (95% CI)	Homozygote Rare OR (95% CI)	Heterozygote OR (95% CI)	Homozygote Rare OR (95%CI)
Smad2	MAD2	18q21.1	rs1787199	A/T	0.46	1.08 (0.92, 1.26)	1.24 (1.03, 1.51)	0.85 (0.69, 1.05)^*
	MADH2		rs1792689	C/T	0.13	0.96 (0.82, 1.12)	1.30 (0.79, 2.13)	0.78 (0.62, 0.98)^*
	JV18		rs4940086	T/C	0.33	1.08 (0.94, 1.25)	1.33 (1.06, 1.66)	1.00 (0.81, 1.23)	1.05 (0.77, 1.42)
Smad3	MAD3	15q22.33	rs750766	G/A	0.48	0.98 (0.84, 1.15)	0.93 (0.77, 1.13)	1.09 (0.89, 1.34)^*
	MADH3		rs893473	C/T	0.17	0.97 (0.84, 1.13)	0.99 (0.69, 1.40)		1.09 (0.73, 1.62)^**
	JV15-2		rs991157	G/A	0.3		0.93 (0.73, 1.18)^**		1.11 (0.79, 1.55)^**
			rs1498506	A/C	0.48	0.87 (0.75, 1.02)	0.69 (0.57, 0.84)	1.10 (0.88, 1.38)	0.96 (0.72, 1.26)
			rs1866317	C/G	0.11	0.98 (0.83, 1.16)	0.92 (0.48, 1.76)	1.12 (0.88, 1.42)	1.65 (0.77, 3.54)
			rs2118610	G/A	0.45	1.11 (0.95, 1.29)	0.94 (0.78, 1.14)	1.02 (0.82, 1.27)	1.02 (0.77, 1.36)
			rs2118611	A/G	0.2	1.03 (0.90, 1.19)^*		0.89 (0.73, 1.09)^*
			rs2414937	G/C	0.2		0.68 (0.47, 0.97)^**	1.01 (0.82, 1.24)	1.02 (0.63, 1.67)
			rs3743343	T/C	0.24	1.10 (0.95, 1.26)	1.15 (0.87, 1.52)	0.97 (0.79, 1.19)	1.10 (0.77, 1.58)
			rs3825977	C/T	0.19	0.95 (0.82, 1.11)	1.01 (0.72, 1.42)	0.96 (0.78, 1.18)	0.76 (0.47, 1.24)
			rs4147358	C/A	0.22	1.08 (0.93, 1.24)	0.99 (0.73, 1.33)	1.03 (0.84, 1.27)	0.89 (0.60, 1.33)
			rs4776892	A/T	0.18	1.02 (0.89, 1.18)^*		0.94 (0.76, 1.16)	1.14 (0.69, 1.88)
			rs7163381	G/A	0.26		0.76 (0.59, 0.98)^**		1.11 (0.79, 1.56)^**
			rs7176870	A/G	0.43	1.08 (0.93, 1.24)^*		1.16 (0.94, 1.42)^*
			rs11071933	C/G	0.33	1.04 (0.90, 1.20)	0.94 (0.75, 1.16)	0.84 (0.69, 1.03)^*
			rs12901071	A/G	0.34		0.68 (0.55, 0.85)^**		0.80 (0.57, 1.10)^**
			rs17293443	T/C	0.22		0.84 (0.60, 1.18)^**		1.81 (1.12, 2.91)^**
Smad4	DPC4	18q21.1	rs10502913	G/A	0.24	1.03 (0.89, 1.19)	0.81 (0.61, 1.08)	1.02 (0.83, 1.25)	1.09 (0.72, 1.67)
	MADH4
TGFβ1	TGFB	19q13.1	rs1800469	G/A	0.31	0.89 (0.78, 1.03)	0.65 (0.51, 0.84)	1.02 (0.84, 1.23)^*
			rs4803455	C/A	0.48	1.25 (1.06, 1.47)	1.43 (1.18, 1.73)	1.06 (0.84, 1.32)	1.04 (0.79, 1.35)
TGFβR1	ALK-5	9q22	rs1571590	A/G	0.2	0.95 (0.82, 1.10)	1.39 (0.98, 1.96)	0.91 (0.74, 1.12)	1.42 (0.85, 2.39)
	SKR4		rs6478974	T/A	0.49	0.85 (0.74, 0.99)^*		0.85 (0.69, 1.05)^*
	LDS1A		rs10733710	G/A	0.2	1.07 (0.93, 1.23)^*		1.17 (0.96, 1.43)^*
	AAT5

Minor Allele Frequency (MAF) based on white control population.

Dominant Model

^**

Recessive Model