Table 2.
Interaction between variants in the TGF-β-signaling pathway and NFκB1 and IKBκB and risk of colon cancer1
| Controls | Cases | Controls | Cases | Controls | Cases | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | N | OR | (95% CI) | N | N | OR | (95% CI) | N | N | OR | (95% CI) | |
| TGFβ1 rs1800469 | ||||||||||||
| GG | GA | AA | ||||||||||
| Smad3 rs3825977 | ||||||||||||
| CC | 610 | 521 | 1.00 | 542 | 419 | 0.92 | (0.77 1.09) | 116 | 80 | 0.80 | (0.58 1.08) | |
| CT | 277 | 230 | 0.99 | (0.80 1.23) | 259 | 201 | 0.90 | (0.72 1.12) | 68 | 35 | 0.57 | (0.37 0.88) |
| TT | 30 | 43 | 1.67 | (1.03 2.70) | 35 | 19 | 0.64 | (0.36 1.14) | 13 | 2 | 0.17 | (0.04 0.75) |
| P Interaction | <0.01 | |||||||||||
| TGFβ1 rs4803455 | ||||||||||||
| CC | CA | AA | ||||||||||
| Smad2 rs4940086 | ||||||||||||
| TT | 232 | 152 | 1.00 | 465 | 360 | 1.21 | (0.94, 1.55) | 207 | 170 | 1.27 | (0.95, 1.70) | |
| TC | 228 | 162 | 1.10 | (0.83, 1.47) | 425 | 335 | 1.24 | (0.96, 1.59) | 196 | 180 | 1.46 | (1.09, 1.95) |
| CC | 58 | 26 | 0.71 | (0.43, 1.18) | 105 | 113 | 1.71 | (1.22, 2.39) | 29 | 50 | 2.72 | (1.64, 4.49) |
| P Interaction | 0.02 | |||||||||||
| Smad3 rs17293443 | ||||||||||||
| TT/TC | 485 | 330 | 1.00 | 947 | 779 | 1.23 | (1.04, 1.45) | 420 | 380 | 1.35 | (1.11, 1.64) | |
| CC | 33 | 10 | 0.46 | (0.22, 0.94) | 48 | 29 | 0.93 | (0.57, 1.51) | 11 | 20 | 2.92 | (1.38, 6.19) |
| P interaction | <0.01 | |||||||||||
| Smad7 rs4939827 | ||||||||||||
| TT | 115 | 106 | 1.00 | 255 | 225 | 0.99 | (0.72, 1.37) | 123 | 110 | 0.99 | (0.69, 1.44) | |
| TC/CC | 403 | 233 | 0.63 | (0.46, 0.86) | 738 | 582 | 0.87 | (0.65, 1.16) | 309 | 290 | 1.04 | (0.76, 1.42) |
| P Interaction | 0.02 | |||||||||||
| TGFβR1 rs6478974 | ||||||||||||
| CC | CA | AA | ||||||||||
| IKBκB rs3747811 | ||||||||||||
| TT | 148 | 155 | 1.00 | 255 | 208 | 0.78 | (0.58, 1.05) | 124 | 84 | 0.66 | (0.46, 0.95) | |
| TA | 270 | 219 | 0.78 | (0.58, 1.04) | 472 | 352 | 0.72 | (0.55, 0.95) | 250 | 171 | 0.67 | (0.49, 0.90) |
| AA | 115 | 104 | 0.87 | (0.61, 1.24) | 239 | 171 | 0.69 | (0.51, 0.94) | 83 | 90 | 1.04 | (0.71, 1.52) |
| P Interaction | 0.04 | |||||||||||
| NFκB1 rs4648110 | ||||||||||||
| TT | 346 | 289 | 1.00 | 615 | 474 | 0.93 | (0.76, 1.14) | 282 | 233 | 1.01 | (0.80, 1.28) | |
| TA | 163 | 175 | 1.29 | (0.99, 1.68) | 311 | 234 | 0.91 | (0.72, 1.15) | 156 | 105 | 0.82 | (0.61, 1.10) |
| AA | 24 | 14 | 0.71 | (0.36, 1.40) | 40 | 23 | 0.69 | (0.40, 1.18) | 19 | 7 | 0.47 | (0.20, 1.15) |
| P Interaction | 0.04 | |||||||||||
| TGFβR1 rs1571590 | ||||||||||||
| AA | AG | GG | ||||||||||
| IKBκB rs37478112 | ||||||||||||
| TT | 347 | 268 | 1.00 | 166 | 156 | 1.24 | (0.94, 1.62) | 14 | 23 | 2.24 | (1.13, 4.44) | |
| TA | 640 | 500 | 1.03 | (0.85, 1.26) | 317 | 209 | 0.86 | (0.68, 1.09) | 35 | 33 | 1.25 | (0.75, 2.06) |
| AA | 273 | 239 | 1.14 | (0.90, 1.44) | 147 | 111 | 1.01 | (0.75, 1.36) | 17 | 16 | 1.24 | (0.61, 2.51) |
| P Interaction | 0.04 | |||||||||||
1
Associations adjusted for age, sex, center and race.
2
Similar associations were observed for NFκB1 rs13117745(C>T), p interaction 0.02.