Table 3.

Associations between variants in the TGF-β-signaling pathway and NFκB1 and Smad2 and Smad3 and rectal cancer risk¹

	Controls	Cases			Controls	Cases			Controls	Cases
	N	N	OR	(95% CI)	N	N	OR	(95% CI)	N	N	OR	(95% CI)
TGFβ1 rs1800469
		GG				GA				AA
Smad3 rs21186102
GG	158	119	1.00		140	104	0.99	(0.70 1.40)	23	35	1.95	(1.09 3.48)
GA	224	166	1.03	(0.75 1.40)	178	156	1.18	(0.86 1.63)	52	35	0.91	(0.56 1.49)
AA	83	72	1.22	(0.82 1.81)	76	61	1.11	(0.73 1.68)	19	4	0.29	(0.10 0.88)
P Interaction			0.01
Smad3 rs41473583
CC	254	204	1.00		220	181	1	(0.76 1.31)	63	31	0.58	(0.36 0.93)
CA	184	137	0.89	(0.89 1.19)	138	115	0.99	(0.72 1.35)	26	34	1.59	(0.92 2.74)
AA	27	16	0.67	(0.35 1.28)	36	25	0.83	(0.48 1.43)	5	9	1.96	(0.64 6.03)
P Interaction			<0.01
TGFβ1 rs4803455
		CC				CA				AA
NFκB1 rs131177454
CC	201	130	1.00		339	274	1.25	(0.95, 1.65)	155	132	1.35	(0.98, 1.86)
CT/TT	52	66	2.00	(1.30, 3.06)	142	105	1.18	(0.84, 1.65)	69	44	1	(0.64, 1.55)
P Interaction			<.01
TGFβR1 rs10733710
		GG				GA/AA
NFκB1 rs46481105
TT	405	270	1.00		207	201	1.45	(1.13, 1.86)
TA/AA	210	184	1.33	(1.04, 1.72)	136	98	1.08	(0.80, 1.47)
P Interaction			<0.01
TGFβR1 rs1571590
		AA				AG				GG
Smad2 rs1792689
CC	455	379	1.00		241	183	0.91	(0.72, 1.16)	15	28	2.42	(1.27, 4.61)
CT/TT	156	112	0.84	(0.63, 1.11)	78	48	0.75	(0.51, 1.11)	14	4	0.32	(0.10, 0.99)
P Interaction			0.003

¹Association adjusted for age, sex, race and center.

²Similar associations were observed for SMAD3 rs991157(G>A), p interaction <0.01.

³Similar associations were observed for SMAD3 rs745103(T>A), p interaction <0.01.

⁴Similar associations were observed for NFκB1 rs4648110(T>A), p interaction 0.02.

⁵Similar associations were observed for NFκB1 rs13117745(C>T), p interaction 0.01.