Table 2.
Summary of 5HT2A-receptor binding studies in the post-mortem brains of suicide victims.
| Radioligand | Type of binding study | Brain region | Result | Ref. |
|---|---|---|---|---|
| [3H]spiperone | Homogenate | PFC 8 and 9 | ↑ Bmax | [59] |
| [3H]ketanserin | Homogenate | PFC 8, 9 and | No change | [73] |
| [3H]ketanserin | Homogenate | PFC 10 | No change | [35] |
| [3H]ketanserin | Homogenate | Frontal cortex | No change | [69] |
| [3H]spiperone | Homogenate | PFC 8 and 9 | ↑ Bmax | [60] |
| [3H]ketanserin | Homogenate | PFC 10 | No change | [72] |
| [3H]ketanserin | Homogenate | PFC 10 and hippocampus | No change in PFC and ↓ in hippocampus | [70] |
| [3H]spiperone | Homogenate | PFC 8 and 9 | ↑ Bmax only in violent suicides | [34] |
| [125I]LSD | Homogenate and sections | PFC 9 | ↑ Bmax and ↑ in sections | [48] |
| [3H]ketanserin | Homogenate and sections | PFC and hippocampus | ↓ Bmax and ↓ in sections in PFC only | [75] |
| [3H]ketanserin | Sections | PFC 9 | ↑ midlayers | [68] |
| [3H]ketanserin | Homogenate | PFC 10 | ↑ Bmax | [65] |
| [3H]ketanserin | Homogenate | PFC 9 and amygdala | ↑ Bmax | [64] |
| [125I]LSD | Sections | Temporal and entorhinal cortex and hippocampus | No change | [57] |
| [3H]ketanserin | Homogenate | PFC 9, 10 and 11 | No change in violent or nonviolent suicides | [51] |
| [3H]ketanserin/[3H]spiperone | Homogenate | PFC 10 and hippocampus | No change | [71] |
| [3H]ketanserin | Sections | PFC 10 and hippocampus | No change | [52] |
| [3H]ketanserin | Homogenate | PFC 8 and 9 | ↑ Bmax | [67] |
| [3H]ketanserin | Homogenate | PFC 9, 10, 11 and hippocampus | No change in PFC and ↓ Bmax in hippocampus | [74] |
| [3H]LSD | Homogenate | PFC 8 and 9 | ↑ Bmax | [66] |
LSD: Lysergic acid diethylamide; PFC: Prefrontal cortex.
Data adapted from [62].