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. 2011 Jan 25;120(2):519–528. doi: 10.1093/toxsci/kfr008

FIG. 4.

FIG. 4.

Effect of sodium arsenite on cell survival in ABCB6-expressing and ABCB6 knockdown cells. Survival of (A) Hep3B and (B) HepG2 cells treated with increasing concentrations of sodium arsenite for 48 h. Immunoblot analysis of ABCB6 expression in Hep3B and HepG2 mitochondria in cells transfected with ABCB6-specific and scrambled (nonspecific) siRNA is presented in the bottom panel (A and B). Survival of (C) ABCB6-overexpressing Hep3B and (D) ABCB6-overexpressing HepG2 cells treated with increasing concentrations of sodium arsenite for 48 h. Immunoblot analysis of ABCB6 expression in ABCB6-expressing and siRNA knockdown cells is presented in the bottom panel (C and D). Porin expression is used as loading control in these experiments. Values represent the mean ± SD; n = 5. Results representative of three independent experiments; “*” Significantly different from siRNA knockdown cells and vector control cells at the respective time points. p < 0.01.