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. Author manuscript; available in PMC: 2012 Jan 4.
Published in final edited form as: Circulation. 2011 Jan 4;123(1):87–97. doi: 10.1161/CIRCULATIONAHA.109.881888

Table 4.

Secondary Prevention to Reduce Cardiovascular Events in PAD

Lipid-lowering therapy Treatment with statin for all PAD patients to target LDL cholesterol<100mg/dl
Target LDL cholesterol < 70mg/dl for high risk patients
Hypertension Treatment Treat to target blood pressure <140/90mmHg (<130/80mmHg for patients with diabetes or chronic kidney disease)
Consider ACE inhibitor in hypertensive patients
Use of beta-blockers is not contraindicated in PAD
Smoking Cessation Provide comprehensive smoking intervention program
Consider pharmacotherapy to support smoking cessation
Antiplatelet Therapy Treat with aspirin 75–325mg or clopidogrel 75mg
Treat with aspirin+thienopyridine in patients with acute coronary syndrome or coronary or peripheral stent

LDL: low-density lipoprotein, ACE: angiotensin converting enzyme

Adapted from American College of Cardiology/American Heart Association 2005 Practice Guidelines for the Management of Patients with Peripheral Arterial Disease (33)