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(A) Ribbon representation of Arc-repressor dimer with one subunit shaded more darkly than the other subunit. The positions of α helices A and B are indicated. (B) Individual variants with excess negative or positive charge may form unstable homodimers alone but form a stable heterodimer in combination. (C) Helical wheel projections showing surface residues in α-helix A (Upper) and α-helix B (Lower) in wild-type Arc, and the A+, A−, B+, and B− variants.
