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. 2010 Nov;51(11):5979–5990. doi: 10.1167/iovs.10-5377

Figure 7.

Figure 7.

Depolarization-induced VDCC-dependent increases in abluminal cell calcium in retinal feeder vessels and capillaries. VDCC function was assessed by determining the maximum nifedipine-sensitive change in intracellular calcium during exposure to solution D (97.5 mM K+). (A) VDCC-dependent increase in the intracellular calcium concentration of abluminal cells located on feeder vessels in nondiabetic (white bars) and diabetic (black bars) microvascular complexes. The number of monitored feeder vessel mural cells was 180, 71, 32, 79, and 52 for the nondiabetic/no additives group, the nondiabetic/DFMO group, the nondiabetic/spermine group, the diabetic/no additives group, and the diabetic/DFMO group, respectively. For each group, 23 ± 3 mural cells were monitored in the nifedipine-containing solutions. (B) VDCC-dependent increase in pericyte calcium in nondiabetic (white bars) and diabetic (black bars) capillaries. For the nondiabetic/no additives group, the nondiabetic/DFMO group, the nondiabetic/spermine group, the diabetic/no additives group, and the diabetic/DFMO group, 62, 61, 22, 27, and 30 capillary pericytes were monitored, respectively. For each group, 18 ± 4 pericytes were monitored in the nifedipine-containing solutions.