Table 2.

Functional Assignment

GO Category	Term	Genes (n)	P
Seven Weeks
BP	Secretion	5	0.01
	Cellular component organization and biogenesis	13	0.014
	Organelle organization and biogenesis	8	0.017
	Posttranslational protein modification	9	0.019
	Cellular monovalent inorganic cation homeostasis	2	0.036
	Establishment of localization	12	0.041
	Localization	13	0.042
	Protein modification process	9	0.047
CC	Organelle membrane	11	0.0007
	Cytoplasmic part	17	0.004
	Endoplasmic reticulum	7	0.01
	Endoplasmic reticulum membrane	5	0.016
	Nuclear envelope-endoplasmic reticulum network	5	0.018
	Endomembrane system	7	0.019
	Endoplasmic reticulum part	5	0.025
	Cytoplasm	21	0.034
	Intracellular organelle part	14	0.038
	Organelle part	14	0.039
	Membrane	23	0.047
MF	Protein binding	24	0.003
	GTP binding	4	0.047
	Guanyl ribonucleotide binding	4	0.049
Sixteen Weeks
CC	Intracellular part	11	0.043
MF	Protein phosphatase regulator activity	2	0.031
	Phosphatase regulator activity	2	0.032
Combined Analysis
BP	Mitochondrion organization and biogenesis	3	0.004
	Nitrogen compound metabolic process	4	0.011
	Cellular metabolic process	13	0.035
	Primary metabolic process	13	0.036
CC	Cytoplasmic part	10	0.0005
	Cytoplasm	11	0.006
	Endoplasmic reticulum	4	0.027
MF	Catalytic activity	10	0.044

DAVID was used to determine the GO categories of the DE genes in mutant retinas at 7 and 16 weeks, separately and regardless of age (combined analysis). For each category, the related term (BP, biologic process; MF, molecular function; and CC, cellular compartment), the number of DE genes, and the significance (P ≤ 0.05) are shown.