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Chemical structures of lobeline, MTD, and MTD analogs incorporating the phenylethylene moiety of MTD into the piperidine ring system with the addition of various phenyl ring substituents. For clarity of presentation, compounds are grouped according to structural similarity. Top, lobeline, MTD, and MTD analogs with no phenyl ring additions. Middle, MTD analogs with dichloro, methoxy, or methyl additions. Bottom, MTD analogs with heteroaromatic phenyl ring substitutions.
