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Inhibition of [3H]DTBZ binding does not predict inhibition of [3H]DA uptake at VMAT2. Data presented are Ki values from analog-induced inhibition of [3H]DTBZ binding and [3H]DA uptake at VMAT2 (Figs. 6 and 7, respectively). Pearson's correlation analysis of these data revealed a lack of correlation (Pearson's r = 0.42; p = 0.13) between the ability of analogs to inhibit [3H]DTBZ binding and [3H]DA uptake at VMAT2.
