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The docked model of the SP-A–TLR4–MD2 complex, as shown in Fig. 4, shows that SP-A interacts with TLR4 in the SP-A–TLR4–MD2 complex in at least four different places. The second monomer of the TLR4-MD2 dimer has been removed from the original model here for clarity. In addition, the noninteracting chains of SP-A and MD2 molecule have been rendered transparent.
