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In vivo antitumor activity of ELR510444. A, dose-dependent antitumor activity was evaluated in the MDA-MB-231 xenograft model with oral dosing of ELR510444 at 3, 6, or 12.5 mg/kg once daily or ABT-751 at 75 mg/kg once daily. B, the plasma compound concentration over time was determined by liquid chromatography-tandem mass spectrometry after a single oral dose of 25 mg/kg.
