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. 2011 Mar;336(3):916–924. doi: 10.1124/jpet.110.173740

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Copyright © 2011 by The American Society for Pharmacology and Experimental Therapeutics

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Fig. 6. — KRS-5Me-4-OCF₃-evoked inhibition of MC spiking activity was blocked by GABA_A receptor antagonists. A, original recording obtained from a MC showed that picrotoxin (20 μM) blocked 20 μM KRS-5Me-4-OCF₃-evoked suppression of neuronal firing. B, the normalized and averaged results showed KRS-5Me-4-OCF₃-evoked inhibitory effects on spiking of MCs in the presence of the GABA_A receptor agonist GABA (50 μM) and antagonist picrotoxin (20 μM) and gabazine (5 μM). **, p < 0.01; ***, p < 0.001. The data for the effect of GABA or KRS-5Me-4-OCF₃ on spiking of MCs were normalized with respect to control condition.