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A scheme of m1 formation and its further metabolism. m1 was generated from ATV spontaneously with M1, and it was trapped using methoxylamine (MeONH2). In mice, m1 can be further metabolized to acid (m2) and conjugated with glycine (m3). m1 may interact with GSH (m4) and be further metabolized to an N-acetylcysteine-conjugate product (m5).
