TABLE 4.
Observed rate constants (kobs) and amplitude of product formation (Rmax) for ticlopidine metabolites; hydroxyticlopidine (M1), 2-oxoticlopidine (M2), thienopyridinium metabolite (M4), ticlopidine N-oxide (M5), and TSOD (M6) after incubation of ticlopidine with CYP2B4 and CYP2B6
| CYP2B4 |
CYP2B6 |
|||
|---|---|---|---|---|
| kobs min−1 | Rmax | kobs min−1 | Rmax | |
| Hydroxyticlopidine (M1) | 0.49 | 0.74 | 0.48 | 2.78 |
| 2-Oxoticlopidine (M2) | 0.48 | 0.72 | 0.50 | 0.94 |
| Thienopyridinium (M4) | 0.56 | 1.00 | N.D. | N.D. |
| Ticlopidine N-oxide (M5) | 0.66 | 1.02 | 0.61 | 0.15 |
| TSOD (M6) | 0.42 | 0.23 | 0.39 | 1.23 |
N.D., not determined because a trace of M4 was observed during analysis of the samples at each sampling time.