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Inactivation rate constants (kinact) of ticlopidine, bupropion, and 7-ethoxy-4-trifluoromethylcoumarin for CYP2B4 and CYP2B6
| Compounds | CYP2B4 |
CYP2B6 |
|---|---|---|
| kinact min−1 | kinact min−1 | |
 Ticlopidine |
0.50a | 0.52a |
 Bupropion |
0.08 | 0.32 |
 7-Ethoxy-4-trifluoromethylcoumarin |
0.02 | 0.10 |
Average of kobs determined by fitting the nonlinear time courses of metabolite formation.
