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. 2010 Nov 10;7(3):209–224. doi: 10.1900/RDS.2010.7.209

Figure 3. Alpha-cells scattered within residual islets in the group of CXCL10 DNA-treated mice with reversal of hyperglycemia.

Figure 3

Immunohistochemical staining of insulin (A, C, E) and glucagon (B, D, F) was performed. A and B: Representative insulitis lesions in established diabetic NOD mice in the group of control DNA mice. C and D: Representative insulitis lesions in the group of CXCL10 DNA-treated mice with reversal of hyperglycemia 8 to 10 weeks after first DNA vaccination. Glucagon-positive cells (α-cells) are scattered within remaining islets (D). E and F: Representative typical distribution patterns of α-cells and β-cells in insulitis lesions of a new-onset diabetic NOD mice. Scale bars: 80 μm.