Table 2.

Statistical analysis of C values

	All PDB	All PDB Grubb test	ModBase Avrg	SEM	p-value*	ModBase Grubb test
ALA	0.231044	0.110456	0.23415	0.008241	< 0.0001	0.209014
ARG	0.250174	0.250937	0.24807	0.007983	< 0.0001	0.619477
ASN	0.291478	1.031238	0.24114	0.007697	< 0.0001	0.41512
ASP	0.284103	0.891901	0.25577	0.006413	< 0.0001	0.846569
CYS	0.049616	3.537912	0.10605	0.015752	-	3.569219
GLN	0.269657	0.61901	0.24635	0.003538	< 0.0001	0.568817
GLU	0.239099	0.041714	0.24119	0.009349	< 0.0001	0.416409
GLY	0.180482	1.065648	0.16437	0.013395	0.0095	1.849155
HIS	0.266794	0.564918	0.24456	0.007517	< 0.0001	0.515768
ILE	0.257308	0.385715	0.24331	0.010592	< 0.0001	0.479012
LEU	0.237448	0.010533	0.22397	0.010956	< 0.0001	0.09126
LYS	0.188001	0.923608	0.2246	0.011423	< 0.0001	0.072917
MET	0.248388	0.217197	0.22974	0.008623	< 0.0001	0.078811
PHE	0.242101	0.098425	0.23494	0.008092	< 0.0001	0.232286
PRO	0.275306	0.725716	0.24454	0.005967	< 0.0001	0.515368
SER	0.247612	0.202537	0.23619	0.006565	< 0.0001	0.268905
THR	0.283274	0.876241	0.23368	0.008642	< 0.0001	0.194947
TRP	0.208734	0.531918	0.23649	0.006956	< 0.0001	0.277834
TYR	0.243902	0.132448	0.22461	0.009417	< 0.0001	0.072408
VAL	0.243296	0.121006	0.22763	0.011549	< 0.0001	0.016623

Statistical analysis of C values for tendency to cluster. Column titles and abbreviations are as in Table 1.

^*the p-value refers to pairwise comparison of calculated values (e.g. “ModBase Avrg” values), between Cys and each one of the other amino acids. In the Grubb test column (Grubb's test for outlier, for N=20), outliers with p-value (for the Grubb's test) < 0.05 are shown in bold. As in Table 1, p-value of the Grubb test refers to the significance of the result associated with the Grubb test (in this case, with α=0.05).