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. 2011 Mar 21;6(3):e18034. doi: 10.1371/journal.pone.0018034

Figure 2. The three-dimensional structure and sequence of the src SH3 domain.

Figure 2

(A) The three-dimensional structure of the complex of the SH3 domain with the VSL12 peptide. The randomized and conserved positions of the SH3 domain in this study are shown in blue and gray, respectively. The peptide ligand VSL12 is shown in red. Structure was visualized by Accelrys DiscoveryStudio 2.1 (PDBid: 1QWF, [21]). (B) The amino-acid sequence of the SH3 domain. The randomized amino acids (X) are shown in blue. In the highly conserved region (gray), red asterisks indicate residues contacting the peptide ligand and black dots indicate residues that are important in determing the domain structure [8], [16].