Table 2.
Association of six variants on 9p21.3: MI study population vs. controls
| Variant | Controls | Risk Allele Frequency | MI Cases n = 976 | Risk Allele Frequency | HW | P value | OR (95% CI) | ||
|---|---|---|---|---|---|---|---|---|---|
| rs1333040 | b) n = 3532 | ||||||||
| C/C | T/T | T: 0.50 | C/C | T/T | T: 0.56 | 0,993 | <0.0001 | 1.621 (1.317-2.994) | |
| 893 | 889 | 181 | 292 | ||||||
| rs10757274 | c) n = 9053 | ||||||||
| A/A | G/G | G: 0.45 | A/A | G/G | G: 0.52 | 0,075 | <0.0001 | 1.904 (1.570-2.309) | |
| 2752 | 1758 | 208 | 253 | ||||||
| rs2383206 | c) n = 9053 | ||||||||
| A/A | G/G | G: 0.47 | A/A | G/G | G: 0.55 | 0,06 | <0.0001 | 1.867 (1.535-2.272) | |
| 2489 | 1981 | 183 | 272 | ||||||
| rs2383207 | b) n = 3532 | ||||||||
| A/A | G/G | G: 0.46 | A/A | G/G | G: 0.55 | 0,25 | <0.0001 | 2.039 (1.654-2.514) | |
| 1016 | 746 | 183 | 274 | ||||||
| rs10757278 | b) n = 718 | ||||||||
| A/A | G/G | G: 0.43 | A/A | G/G | G: 0.52 | 0,062 | <0.0001 | 1.941 (1.458-2.583) | |
| 224 | 128 | 211 | 243 | ||||||
| rs1333049 | a) n = 999 | ||||||||
| G/G | C/C | C: 0.46 | G/G | C/C | C: 0.52 | 0,233 | <0.0001 | 1.653 (1.280-2.135) | |
| 292 | 205 | 212 | 246 |
Genotype distribution and allelic frequencies of the investigated SNPs on 9p21.3 of the overall study cohort were compared with control data of the PopGen cohort (a) [11], the Iceland B collective (b) [4] or the Copenhagen City Heart Study (c) [3]. HW: P value for Hardy-Weinberg equilibrium test. P values and Odds ratios (OR) were calculated for the high-risk homozygous alleles.