Table 4.

Association of six variants on 9p21.3: MI study subpopulation with a positive family history vs. MI study subpopulation with a negative family history

Variant	Negative Family History n = 404		Risk Allele Frequency	Positive Family History n = 361		Risk Allele Frequency	P value	OR (95% CI)
rs1333040
	C/C	T/T	T: 0.53	C/C	T/T	T: 0.57	0.102	1.426(0.932-2.180)
	81	107		60	113
rs10757274
	A/A	G/G	G: 0.48	A/A	G/G	G: 0.56	0.002	1.940(1.269-2.964)
	96	83		65	109
rs2383206
	A/A	G/G	G: 0.51	A/A	G/G	G: 0.57	0.015	1.703(1.108-2.618)
	81	89		62	116
rs2383207
	A/A	G/G	G: 0.51	A/A	G/G	G: 0.58	0.016	1.696(1.103-2.608)
	80	89		62	117
rs10757278
	A/A	G/G	G: 0.47	A/A	G/G	G: 0.55	0.003	1.923(1.256-2.944)
	96	79		67	106
rs1333049
	G/G	C/C	C: 0.48	G/G	C/C	C: 0.55	0.003	1.896(1.241-2.898)
	98	81		67	105

Genotype distribution and allelic frequencies of the investigated SNPs on 9p21.3 of the study subpopulation with a positive family history were compared with the study subpopulation with a negative family history. P values and Odds ratios (OR) were calculated for the high-risk homozygous alleles.