Table 2. Previously published or putative miRNA targets with potential implications in MDS.
| miRNA | miRNA deregulation in MDS | Previously published or putative targets |
|---|---|---|
| miR-10a | ↑ Early MDS ↓ advanced MDS | HOX genes (eg HOXA1, HOXA3, HOXB3)14 |
| miR-34a | ↑ Early MDS | BCL2,15 MEK1,16 MET,17 MYCN, SPI1a |
| miR-378 | ↓ In 5q− syndrome | SUFU,18 ETV6, BCL2L2a |
| miR-127 | ↑ In all MDS | BCL6,19 BLIMP1,20 XBP120a |
a
Genes with inverse association of their transcript levels (compared with miRNA expression) in our previously published mRNA expression data.11