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. 2010 Nov 24;19(3):287–292. doi: 10.1038/ejhg.2010.213

Figure 1.

Figure 1

(a) Axial T2-weighted image of the proband at age 2 months showing diffuse hyperintense changes in the deep white matter and the U-fibers associated with cortical atrophy. (b) Coronal T2-weighted image of the proband at age 2 months shows diffuse white matter changes and periventricular cysts, involving the head of the caudate bilaterally. (c) Fourth pregnancy. MRI-coronal HASTE at 33 weeks of gestation showing cysts of the caudate nuclei and increased signal in the white matter of the temporal lobes. (d) Fourth pregnancy. US in the parasagittal transvaginal plane at 34 weeks 2 days showing dotted areas of increased echogenicity in the caudate and thalamus (arrow). (e) Parasagittal transvaginal plane at 34 weeks 2 days showing a hypoechogenic rim around the posterior horn of the lateral ventricle. (f) Fifth pregnancy. MRI-sagittal HASTE, 33 weeks of gestation of the fifth pregnancy. Cystic lesions of frontal white matter and caudate nucleus enlarged lateral ventricle. (g) Fifth pregnancy. US in the parasagittal view at 34 weeks 2 days showing an abnormally echogenic caudate (white arrow). (h) Fifth pregnancy. Coronal plane at 34 weeks 2 days showing dotted areas of increased echogenicity in the caudate (arrow). Note the irregular shape of the lateral ventricle on the same side.