Table 3. Head circumference, serotonin blood levels, and global peptiduria by ITGB3 and SLC6A4 genotypes.
| GENOTYPES | Head circumference | 5-HT blood levels | Global peptiduria | ||||
|---|---|---|---|---|---|---|---|
| ITGB3, SNP1: rs2317385 | G/G | 82.5±47.5 N=144 | K–W χ2=3.542 | 317.3±25.0 N=99 | Pairwise U-test: | 345.3±23.0 N=145 | K–W χ2=1.676 |
| G/A | 75.0±47.4 N=60 | 2 d.f., P=0.170 | 468.9±44.0 N=36 | GG vs GA+AA | 309.6±32.3 N=41 | 2 d.f., P=0.433 | |
| A/A | 97.5 N=3 | 261.0 N=1 | U=1087.0, | 267.0±168.0 N=3 | |||
| P=0.001 | |||||||
| ITGB3, SNP5: rs5918 | T/T | 82.5±47.5 N=182 | K–W χ2=1.377 | 313.7±23.9 N=102 | K–W χ2=1.207 | 344.3±17.4 N=151 | K–W χ2=0.793 |
| C/T | 75.0±47.5 N=74 | 2 d.f., P=0.502 | 314.2±29.2 N=48 | 2 d.f., P=0.547 | 355.3±37.4 N=74 | 2 d.f., P=0.673 | |
| C/C | 82.5±47.5 N=9 | 421.1±104.5 N=8 | 281.2±59.0 N=6 | ||||
| ITGB3, SNP8: rs12603582 | G/G | 82.5±47.5 N=121 | K–W χ2=0.408 | 368.4±31.6 N=77 | K–W χ2=0.181 | 331.6±26.1 N=107 | K–W χ2=1.586 |
| G/T | 78.7±47.5 N=74 | 2 d.f., P=0.815 | 353.7±35.0 N=52 | 2 d.f., P=0.913 | 340.6±25.8 N=74 | 2 d.f., P=0.453 | |
| T/T | 86.2±47.5 N=10 | 311.2±97.5 N=5 | 366.1±171.9 N=8 | ||||
| SLC6A4, 5-HTTLPR | S/S | 82.5±47.3 N=69 | K–W χ2=4.329 | 390.3±43.9 N=41 | K–W χ2=4.821 | 325.2±23.7 N=50 | K–W χ2=0.260 |
| S/L | 82.5±47.5 N=123 | 2 d.f., P=0.115 | 282.0±21.4 N=80 | 2 d.f., P=0.09 | 364.4±28.4 N=114 | 2 d.f., P=0.878 | |
| L/L | 90.0±35.0 N=82 | 385.0±41.0 N=49 | 329.6±22.9 N=76 | ||||
Abbreviation: K–W, Kruskal–Wallis test (non-parametric ANOVA).
Data are expressed as mean±SEM, except for head circumference, which is expressed as median±semi-interquartilic range (IQR/2). Nominal P-value are reported; highlighted in bold, statistically significant results surviving Bonferroni's correction (significance set at P<0.0041).