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. Author manuscript; available in PMC: 2011 Jun 10.
Published in final edited form as: Aquat Toxicol. 2010 Feb 6;98(2):157–164. doi: 10.1016/j.aquatox.2010.02.001

Figure 2.

Figure 2

Transfer from freshwater (FW) to seawater (SW) increased the plasma membrane abundance of CFTR in control (1-8 hr) but not in arsenic treated fish. A) Summary of data. Fish were adapted to freshwater for two weeks, then exposed to arsenic (12,000 ppb) or vehicle for 48 hours and then placed in seawater containing arsenic or vehicle for 1 hr, 3 hr, and 8 hr. After the indicated times, opercula membranes were isolated and the amount of CFTR in the apical plasma membrane in control (hatched bars) and arsenic treated fish (solid bars) was measured as described in methods. Data presented as percent of FW. N=6-12/group. *P<0.05 versus FW and **P<0.05 versus FW. B) Representative Western blots of CFTR in the plasma membrane.