Table 1.
Effect of EESC and EAF on pentobarbitone-induced sleeping time, sleep latency and rotarod test in rats
| Group | Treatment | Dose | Sleep latency (seconds) | Sleeping time (min) | Rotarod activity (seconds) |
|---|---|---|---|---|---|
| I | Vehicle | 1 mL | 244.5 ± 3.40 | 172.33 ± 2.42 | 258.80 ± 34.00 |
| III | EESC | 125 mg/kg | 235.83 ± 3.91 | 181.83 ± 2.78 | 231.45 ± 23.49 |
| IV | EESC | 250 mg/kg | 202.17 ± 3.38*** | 192.33 ± 3.76** | 241.70 ± 22.90 |
| V | EESC | 500 mg/kg | 198.00 ± 2.51*** | 261.78 ± 1.98*** | 191.47 ± 16.79 |
| VI | EAF | 125 mg/kg | 230.17 ± 2.42 | 197.83 ± 1.06** | 226.82 ± 32.45 |
| VII | EAF | 2750 mg/kg | 177.83 ± 3.91*** | 375.17 ± 2.66*** | 237.30 ± 28.87 |
| VIII | EAF | 500 mg/kg | 124.83 ± 2.76*** | 364.50 ± 3.78*** | 206.54 ± 43.80 |
EESC: Ethanolic extract of Smilax china Linn.; EAF: Ethyl acetate fraction; Values are mean ± SEM (n = 6) statistical significance was determined by ANOVA, followed by Dunnett’s “t” test (n =6);
***
P < 0.001,
**
P < 0.01,
*P < 0.05 when compared against control aP < 0.001, bP < 0.01, when compared against standard