Table 3.

Effect of EESC and EAF on PTZ-induced seizures in mice

Group	Treatment	Dose	Onset time (seconds)	Duration of clonus (seconds)	Protection (%)
I	Vehicle	1 mL	190.33 ± 1.83	8.16 ± 0.40	0
II	Diazepam	2 mg/kg	0	0	100***
III	EESC	100 mg/kg	268.33 ± 13.01a	4.83 ± 0.30**	54
IV	EESC	200 mg/kg	298.33 ± 25.48***a	14.83 ± 0.30**	100***
V	EESC	400 mg/kg	481.83 ± 2.83***a	19.16 ± 0.65**	100***
VI	EAF	100 mg/kg	289.16 ± 7.79***a	2.66 ± 0.21**	83**
VII	EAF	200 mg/kg	356 ± 6.42a	2.83 ± 0.16**	100***
VIII	EAF	400 mg/kg	495 ± 9.83***a	5.5 ± 0.34**	100***

EESC: Ethanolic extract of Smilax china Linn.; EAF: Ethyl acetate fraction; Values are mean ± SEM (n = 6). Statistical significance was determined by ANOVA, followed by Dunnett’s “t” test (n=6);

^***P < 0.001,

^**P < 0.01,

^*P < 0.05 when compared against control

^aP < 0.001,

when compared against standard