Table 1.

Results of analyses of SYNERGY. For all-cause mortality to t_max = 1 year and estimation of the hazard ratio exp(β) in (3.1): intent-to-treat analysis; naive analysis in which event times are artificially censored at times of discontinuation for any reason (censor, all); naive analysis in which event times are artificially censored at times of optional discontinuation (censor, optional); naive proportional hazards analysis with time-dependent treatment indicators as covariates (time-dependent); and inverse risk set weighted analyses using the indicated choice of w(u, Z) (inverse weighted). For the binary outcome TIMI bleeding at t_max = 30 days and estimation of the odds ratio exp(β) at the end of Section 5: intent-to treat analysis; naive analysis deleting all subjects discontinuing treatment for any reason (delete); and inverse weighted analysis. In each case, p-value corresponds to test of null hypothesis β = 0, and standard errors were obtained via the delta method

Method	Estimate	95% confidence interval	p-value
Hazard ratio, 1 year all-cause mortality
Intent-to-treat	1.06	(0.92–1.22)	0.44
Censor, all	1.03	(0.86–1.23)	0.77
Censor, optional	1.08	(0.92–1.26)	0.33
Time-dependent	1.03	(0.86–1.23)	0.77
Inverse weighted
w(u, Z) ≡ 1	1.08	(0.92–1.26)	0.36
w(u, Z) depends on Z	1.07	(0.91–1.25)	0.42
Odds ratio, TIMI bleed at 30 days
Intent-to-treat	1.21	(1.05–1.40)	0.009
Delete	1.06	(0.88–1.27)	0.56
Inverse weighted	1.23	(1.05–1.40)	0.009