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Schematic presentation of the VEGF ligands and their interaction with membrane-bound and soluble (secreted) VEGF receptors. Notably, inhibitory effects are exerted by sVEGFR-1 (anti-hemangiogenesis) and sVEGFR-2 (anti-lymphangiogenesis). ). Neuropilin-2 (NRP-2) also interacts with VEGFR-3 on lymphatic endothelial cells, which is not shown in this scheme . NRP-1: Neuropilin-1. Modified from: http://www.rosenthallab.com/gallery/images/VEGF_VEGFR.jpeg
