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. Author manuscript; available in PMC: 2012 Mar 15.
Published in final edited form as: Blood Cells Mol Dis. 2011 Feb 4;46(3):212–219. doi: 10.1016/j.bcmd.2011.01.001

Figure 4. Delayed silencing of the transgenic human ε-globin gene in MBD2 knockout mice.

Figure 4

RNA from 10.5 dpc yolk sac and 16.5 dpc fetal liver cells was extracted and assayed by real time pcr and normalized to cyclophilin gene expression. (A) The light shaded bar shows expression of the ε-globin gene in dpc 10.5 yolk sac and the dark shaded bar shows expression in dpc 16.5 fetal liver in wild type LCRε transgenic mice as indicated. (B) Expression levels of ε-globin gene expression in 16.5dpc wild-type and MBD2−/− embryonic liver cells.