Figure 1.

Aging is associated with distinct gene expression patterns in islets. Genomic microarray mRNA expression analysis of islets in the basal state, comparing islets from young mice (1.5 months of age) versus those from old mice (14 or 19 months of age). The two pair-wise arrays comprising in this data set (N2) represented the expression sets that exhibited the least exocrine contamination. (A) Heat map of the 91 elements of the PancChip microarray that were differentially expressed 1.5-fold change (FC) or more. Red: genes with higher expression in islets from young versus old mice. Green: genes with lower expression in islets from young versus old mice. (B and C) The most differentially expressed genes in islets from young versus old mice. (B) Genes that were expressed at higher levels in young mice. (C) Genes that were expressed at lower levels in young mice.