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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Mol Microbiol. 2011 Jan 6;79(5):1194–1203. doi: 10.1111/j.1365-2958.2010.07500.x

Figure 1. Multiple sequence alignment of Sec- and Cys-containing Grxs.

Figure 1

Catalytic Sec (U) and Cys residues are highlighted in red. Resolving Cys residues in the Sec- and Cys-containing dithiol Grxs are shown in blue. Two variant amino acid sequences in the GSH binding region of Clostridium selenoprotein Grx are indicated by arrowheads. Human and zebrafish Grx3s are represented as monothiol Grxs that contain the CGFS catalytic motif. GenBank accession numbers are as follows: Clostridium sp. OhILAs Grx1, 158321154; Clostridium Grx2, 158139258; E. coli Grx1, 146273; Saccharomyces cerevisiae Grx1, 5328; Drosophila melanogaster Grx1, 16226192; Mus musculus Grx1, 31981458; Homo sapiens Grx1, 531405; H. sapiens Grx2, 15077235; H. sapiens Grx3, 95113651; Danio rerio Grx3, 54400406.