Table 3.

Summary of factors associated with increased risk of grades 2-4 acute and chronic GVHD

Factor	Acute GVHD		Chronic GVHD
	Previously reported*	Current study	Previously reported†	Current study‡
HLA mismatch or unrelated donor	yes	yes	yes	yes
Older patient age	yes	no	yes	yes
Older donor age	yes	yes	yes	yes
Female donor for male recipient	yes	yes	yes	yes
Parity of female donor (allosensitization)	yes	§	yes	§
Intensity of conditioning regimen	yes	‖	no	‖
Mobilized blood cell graft	no/yes	no	yes	yes
Donor lymphocyte infusion	yes	¶	yes	¶
Prior acute GVHD	n/a	n/a	yes	yes

n/a indicates not applicable.

^*Results from selected large studies.^{7-10,12,14,16,21,22}

^†Historically defined chronic GVHD.

^‡By NIH chronic GVHD criteria.

^§Not consistently reported or data not available for analysis.

^‖DLI was treated as a competing risk in our analysis for risk factors for GVHD.

^¶All patients received a high-intensity conditioning regimen.