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Noxa mediates cell-cycle control of apoptosis. (A) qPCR analysis of relative Noxa mRNA in p18+/+ and p18−/− rBCs (A) before and after stimulation with BAFF or anti-IgM for 48 hours and (B) before and after stimulation with anti-IgM and anti-CD40 for 72 hours and infection with a Noxa shRNA- or nonsense shRNA (Cntl)-expressing retrovirus or left uninfected. (C) Total live cells from cultures in panel B at 48 and 72 hours after shRNA-retrovirus infection.
