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. 2011 Jan 4;117(9):2681–2690. doi: 10.1182/blood-2010-02-267906

Figure 7.

Figure 7

Development of MDS/MPN is associated with disrupted expression of essential myeloid transcription factors. (A-C) Real-time PCR analysis of indicated transcripts using RNA isolated from CD11b+/Gr-1low/− cells from MDS/MPN NR4A1+/−NR4A3−/− mice (n = 3, at 4-10 months, blast levels between 12% and 18%; gray columns) and control NR4A1+/−NR4A3+/+ mice (n = 7, at age 4-10 months; black columns). Animals with greater than 10% blasts were considered advanced diseased based on the criteria of Sokal et al and the International Bone Marrow Transplant Registry.42,43 (D-F) Real-time PCR analysis of indicated transcripts using RNA isolated from CD11b+/Gr-1low/− cells from 6-week-old preneoplastic NR4A1−/−NR4A3+/− mice (gray columns, n = 3) and 6-week-old NR4A1+/+NR4A3+/− control mice (black columns, n = 3). All results were normalized to B2m expression. *P < .05. **P < .02. Error bars represent SEM.