Table 3.
Chemokines and receptors with a suspected role in IBD pathophysiology
| Name | Gene | Other names | Receptor | Uniprot | Related disease | Target cells |
| CC chemokines | ||||||
| CCL2 | Scya2 | MCP1 | CCR2 | P13500 | CD + UC | Th/mono/baso |
| CCL3 | Scya3 | MIP1a | CCR1 | P10147 | CD + UC | Tc |
| CCL4 | Scya4 | MIP1b | CCR1, CCR5 | P13236 | CD + UC | Th |
| CCL5 | Scya5 | RANTES | CCR5 | P13501 | CD + UC | Th/mono/baso |
| CCL7 | Scya7 | MARC, MCP3 | CCR2 | P80098 | CD + UC | mono/baso |
| CCL8 | Scya8 | MCP2 | CCR1, CCR2B, CCR5 | P80075 | CD + UC | neutro/baso/mono |
| CCL25 | Scya25 | TECK, Ckb15 | CCR9 | O15444 | CD + UC | Th17 |
| CXC chemokines | ||||||
| CXCL1 | Scyb1 | Gro-a, GRO1, NAP3, KC | CXCR2 | P09341 | CD + UC | neutro/baso |
| CXCL2 | Scyb2 | Gro-b, GRO2, MIP2a | CXCR2 | P19875 | CD; UC? | neutro/baso |
| CXCL5 | Scyb5 | ENA78 | CXCR2 | P42830 | CD + UC | neutro |
| CXCL6 | Scyb6 | GCP2 | CXCR1, CXCR2 | P80162 | CD + UC | neutro/baso |
| CXCL8 | Scyb8 | IL8, NAP1, MDNCF, GCP1 | CXCR1, CXCR2 | P10145 | CD + UC | neutro/baso |
| CXCL10 | Scyb10 | IP10, CRG2 | CXCR3 | P02778 | CD + UC | T/mono |
| CXCL12 | Scyb12 | SDF1, PBSF | CXCR4 | P48061 | CD + UC | T/B |
| CX3C chemokines | ||||||
| CX3CL1 | Scyd1 | Fractalkine, neurotactin, ABCD3 | CX3CR1 | P78423 | CD + UC | mono/DC |
CD, Crohn disease; DC, dendritic cell; Th, T helper cell; Tc, T cytotoxic cell; mono, monocyte; baso, basophil; neutro, neutrophil; UC, ulcerative colitis.