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Embryo lethality in XX embryos inheriting XistINV on the paternal X chromosome. Embryos were dissected from uteri at E6.5-10.5. Xm carries the wild-type Xist allele and so male (XmY) embryos are wild type. Xp carries the XistINV allele and so females are heterozygous for the inversion. The embryos shown are representatives from three litters dissected at each gestational age. Xm, maternally transmitted X chromosome; Xp, paternally transmitted X chromosome. Scale bars: 500 μm.
